|
KMID : 0043320120350122147
|
|
Archives of Pharmacal Research
2012 Volume.35 No. 12 p.2147 ~ p.2151
|
|
|
Three new 11,20-epoxy-ent-kauranoids from Isodon rubescens
|
|
Liu Xu
Zhan Rui
Wang Wei Guang
Du Xue
Li Yan
Zhang Peng
Pu Jian Xin
Wu Ji Zhou
Sun Han Dong
|
|
|
Abstract
|
|
|
|
Three rare and new 11,20-epoxy-ent-kaurane diterpenoids, named jianshirubesins D-F (1-3), along with one known analogue (4), were isolated from the aerial parts of Isodon rubescens. Their structures were established by analysis of spectroscopic data. Found in the MTT assay to evaluate the cytotoxicity of compounds 1, 2, and 4, only 1 could selectively inhibit certain cell lines from proliferating. In addition, a simple structure-activity relationship discussion might suggest a new bioactive moiety, different from the α,β-unsaturated ketone group.
|
|
|
KEYWORD
|
|
|
Jianshirubesins D-F, 11, 20-Epoxy-ent-kauranoids, Isodon rubescens, Cytotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|